Isotretinoin and Psychiatric Effects
نویسندگان
چکیده
Isotretinoin is a vitamin A derivative that has been commonly used by dermatologists for the treatment of acne. Isotretinoin has many dose-related side-effects, which have caused many debates lately, especially related to psychiatric and gastrointestinal issues. Since the introduction of isotretinoin into the market, there have been a growing number of reported cases of psychiatric side-effects, including: depression, suicide, aggression, psychosis, mood swings, violent behaviour, hostility, bipolar disorder, and obsessive compulsive disorder. According to some animal studies, isotretinoin can pass the blood-brain barrier and it may cause serious side-effects. On the other hand, it has been shown that isotretinoin can decrease the psychiatric symptoms of many psychiatric patients. Because a definitive causal relationship has not been established, it remains unclear as to whether isotretinoin therapy leads to psychopathology. In this review article, we evaluate the published articles about the psychiatric side-effects of isotretinoin and discuss the psychopathologic effects of isotretinoin.
منابع مشابه
Isotretinoin and psychopathology: a review
Isotretinoin, a synthetic oral retinoid that is used against severe nodulocystic acne, has been associated with various psychiatric side effects such as depression, suicidality and psychotic symptoms. A great number of reports on its effects have been published since its introduction into the market. However, a causal relationship has not been established and the link between isotretinoin use a...
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